Sales of Pseudoephedrine

There have been very rare reports of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) with pseudoephedrine.

Patients and caregivers should be advised to be alert to the symptoms for PRES and RCVS. They should be advised to stop the medication immediately and to seek urgent medical attention if the symptoms occur.

If someone presents with symptoms of PRES or RCVS, ask about their medication history. Symptoms include:

• sudden severe headache or thunderclap headache
• sudden onset of nausea and vomiting
• confusion
• seizures
• visual disturbances